Mr Musaab YassinOxford Men’s Health
← Oxford Men’s Health

What I treat · Peyronie’s disease

Peyronie’s disease, and a shape that has changed

A change in shape arrives without warning, is difficult to raise with anyone, and is too often met with “nothing can be done”. That has not been true for a long time.

Scar tissue forms in the sheath around the erectile cylinders; healthy tissue expands during an erection and scar does not, so the shaft bends. Almost every decision turns on one question first — is it still changing, or has it settled? While it is still moving, surgery is unsafe but injection therapy and traction are not. Once the shape has held steady, correction is both appropriate and highly effective.

Erections commonly suffer alongside the curve, and the two are assessed in the same appointment rather than separately — erectile dysfunction has a page of its own, because where erections have already failed the operation that corrects both problems at once is a different conversation entirely.

The honest trade-off Plication straightens moderate curves in 85–95% with very little risk to erections, but shortens by roughly 1 cm for every 15 degrees corrected. Grafting preserves length and handles severe curves, at a 15–25% risk of new erectile dysfunction. Where erections have already failed, an implant corrects both problems at once — but permanently replaces natural erectile tissue.

Assessment and treatment are held in one appointment. Where the examination and, if it is needed, the ultrasound point to injection therapy, the first Perovial injection can be given the same day — so most men start treatment on the visit they were assessed on, rather than waiting for a second appointment to begin.

Perovial is hyaluronic acid, injected into the plaque while the disease is still active. It is a prescription-only medicine, given in clinic, and it is offered only after an assessment has established that the disease is in a phase where it is worth giving. A course runs weekly for roughly ten to twelve weeks.

Read the first injection correctly It is free so that you are not billed for starting something you then decide against — not as a trial of the drug. One injection cannot tell you whether a course will work, and nobody should present it that way. If you do go on, it counts as treatment one.

Written and reviewed by Mr Musaab Yassin, Consultant Urological Surgeon & Andrologist. FRCS (Urol) · GMC 6118378 ·

Perovial, the hyaluronic acid preparation used for intralesional injection in Peyronie’s disease.
Perovial — the hyaluronic acid preparation used for intralesional injection while the disease is still active. Manufacturer’s image, IBSA.

Evidence Notes · Peyronie’s disease

Read the case against a treatment, before you agree to it.

Every device company publishes its best trial and every clinic quotes the most flattering figure from it. These are the appraisals that belong to this condition — three of the twelve — including the unflattering findings, and the places where good studies disagree with one another.

Peyronie’s disease

StrongRandomised trials and systematic reviews agree.
ReassuringConsistent, but resting partly on observational work.
ModerateReal, from smaller or less rigorous studies.
LimitedToo little evidence to rely on. Said plainly.
The full collection, all twelve → How to read a trial result

Before your visit

Fifteen minutes now saves twenty in the room.

Complete the questionnaire before you come. Nothing is saved or transmitted — you print the summary or copy it into an email, and it stays entirely in your control.

03 · Peyronie’s

Peyronie’s disease

Onset, whether the shape is still changing, pain, angle and erectile function.

Open the questionnaire →
What to bring Three things

Any previous scans or reports, a list of your current medication, and the completed questionnaire if you have had time.

How long Allow up to an hour

The consultation itself takes at least twenty minutes. Allow up to an hour if you are having a flow test, a scan, bloods or a urine test on the day.

Coming with someone Welcome

Partners are welcome throughout, and for fertility discussions it is often better if you both come.

The other areas

Each area has a page of its own.

Booking, fees and the four ways to get in touch are on the practice page.

Call the practice Send an enquiry