Nuffield Health The Manor Hospital, Oxford
Mr Musaab Yassin · Consultant Urological Surgeon & Andrologist
Peyronie's disease behaves differently in different men, and what can usefully be done depends on which phase it is in. Assessment establishes that first — before any treatment is discussed.
01 · When to seek advice
A great many men wait months, on the assumption that nothing can be done until the condition stops changing. That is the opposite of the case: the active phase is when assessment is most useful, because some options exist only while the disease is still moving.
Arrange an assessment
None of these is an emergency. All of them are worth a consultation rather than a wait.
02 · Understanding the condition
Fibrous scar tissue — the plaque — develops within the elastic sheath around the erectile cylinders. Healthy tissue expands during an erection and scar does not, so the shaft is tethered and forced to bend, indent or shorten. It can also affect erections, confidence and relationships, and those consequences matter as much as the geometry.
What can sensibly be offered turns on one question before any other: is the disease still active, or has it stabilised? Rather than relying on a fixed number of months, that judgement is made from your symptoms, your history, examination, and imaging where it is indicated.
Active phase
Pain may be present, and the curve, the plaque or the overall shape may still be developing. The picture is not yet settled, so treatment decisions are made on the individual clinical findings rather than on a protocol.
Reconstructive surgery is not appropriate while the shape is still moving. Non-surgical options belong to this phase.
Stable phase
Pain has usually settled and the curvature has become consistent from one month to the next. The range of options that can reasonably be considered is different from those appropriate during active disease.
Once the shape has held steady, surgical correction becomes both appropriate and, for the right deformity, highly effective.
There is no timetableThe active phase can last many months, and it does not end on a particular date. It is identified from symptoms, clinical history and specialist assessment — not from how long you have had it.
03 · Specialist assessment
The consultation exists to establish three things: what has changed, how much it is affecting you, and which options are clinically suitable in your case. Not every man who attends will be advised to have treatment.
Pain, changes in curvature or shape, erectile function, and the effect on sexual activity and wellbeing. This last part is not a formality — it often determines what is worth doing.
History
Examination of the plaque, and a judgement on whether the disease appears active or stable. This is the finding that most shapes what follows.
Examination
A penile ultrasound, sometimes with a pharmacological erection assessment, to assess anatomy, the plaque and blood flow. It is arranged when the result would alter the plan, not routinely.
Investigation
04 · One of the options
A prescription-only medicine containing highly purified hyaluronic acid sodium salt, given in a specialist clinical setting to selected adults whose Peyronie's disease is in the active phase.
Suitability is decided by a consultant after assessment. It will not be the right option for every man, and depending on the phase of the disease, the characteristics of the plaque, the pattern of deformity and what matters most to you, another approach may be more appropriate — including doing nothing for the time being.
0.8% hyaluronic acid sodium salt, supplied as 16 mg in 2 mL.
Weekly appointments across approximately 10 to 12 weeks, tailored after assessment.
Administered by an appropriately qualified specialist, not self-administered.
What the evidence does and does not support
Published studies have looked at pain, curvature, plaque dimensions, erectile function and patient-reported outcomes. That evidence is made up largely of small, non-randomised studies with limited follow-up — which is a genuinely different thing from the randomised trial evidence behind the established operations for this condition.
It is reasonable to consider on that basis. It is not reasonable to present it as equivalent, and individual results vary. No particular outcome can be guaranteed, and anyone who tells you otherwise is overselling it.
05 · The course
If treatment is agreed, this is the shape of it. The weekly commitment is the part worth thinking about before you start.
Symptoms, clinical history, and the effect the condition is actually having. The options are set out with their limitations, not only their intentions.
This establishes the baseline against which any change is later judged. Without a proper baseline, "improvement" is an impression rather than a measurement.
Normally weekly across approximately ten to twelve weeks. Each appointment is short, but the course asks for a consistent commitment over roughly three months.
Your response is reviewed against the baseline, and the appropriate next steps discussed — which may include no further treatment.
06 · Safety and aftercare
The benefits, limitations, alternatives and risks that apply to you specifically are explained in the consultation. This page is a general overview and does not replace the complete safety information given there.
Local reactions around the treatment area may occur, and are generally temporary.
Before treatment your consultant checks for reasons it may not be appropriate for you, including active infection, established calcification within the plaque, certain patterns of deformity, and any known sensitivity to an ingredient.
Where one of those applies, a different approach is discussed instead.
After each appointment
Follow the individual instructions your clinical team gives you, which take precedence over anything on this page. Contact them if you are concerned about any reaction — particularly increasing pain, spreading redness, significant swelling or fever.
07 · Costs
Published so that you can weigh the commitment before the consultation rather than after it. What is clinically appropriate is confirmed at assessment, and you are under no obligation to proceed.
| Item | What is included | Patient price |
|---|---|---|
| Initial specialist Peyronie's assessment | Consultant assessment, clinical evaluation and treatment planning. | £250–£300 |
| First Perovial® treatment | Medicine, local anaesthetic, treatment consumables and facility costs. If you decide afterwards not to continue with a full programme, there is no charge for this first treatment. | Complimentary |
| Ten-treatment programme | Ten treatments in total, including the complimentary first treatment. Medicine, local anaesthetic, consumables and facility fees throughout. | £4,500 |
| Twelve-treatment programme | Twelve treatments in total, including the complimentary first treatment. Medicine, local anaesthetic, consumables and facility fees throughout. | £5,000 |
| Post-treatment assessment | Consultant review and assessment of treatment response. | Included |
The complimentary first treatmentIt counts as treatment one if you go on to a ten- or twelve-treatment programme. If you decide not to continue, there is no charge for it.
| Investigation | What it establishes | Patient price |
|---|---|---|
| Penile ultrasound, with or without pharmacological erection assessment | Plaque characteristics, penile anatomy, vascular response and curvature, where those findings would change the plan. | £300–£400 |
| Repeat penile ultrasound, if required | Objective reassessment after treatment, where clinically indicated. | £250–£300 |
08 · Your consultant
Not delegated. The person who assesses you is the person who treats you and who reviews the result.
Consultant Urological Surgeon and Andrologist, practising in Oxford and London, with fellowship training in andrology and reconstructive urology. Peyronie's disease sits in the middle of that sub-speciality — phase assessment, injection therapy, traction, and the corrective surgery that follows when the shape has settled.
Consultations run at Nuffield Health The Manor Hospital in Oxford and The Lister Hospital in central London, in English or Arabic.
09 · Common questions
You often cannot know on your own, and that is the point of the assessment. Pain, and a curve or deformity that is still changing, both suggest active disease — but there is no single test and no fixed timetable. The judgement comes from your symptoms, your history and examination, with imaging where it would change something.
Please contact the clinic to ask about current appointment and referral arrangements. The team can tell you what information is needed before your consultation.
If treatment is clinically appropriate, appointments are normally weekly across approximately ten to twelve weeks. Your exact plan is confirmed after assessment. It is worth being realistic about that commitment before starting rather than partway through.
No. Research has reported changes across several clinical and patient-reported measures, but that research is limited in size and design, and individual responses vary considerably. Realistic expectations, the limitations of the evidence, and the alternatives in your circumstances are all discussed before you decide anything.
You will be given individual aftercare instructions. In general, avoid sexual activity and vigorous physical activity for 24 to 48 hours, and contact the clinical team if you are concerned about a reaction.
Then you will be told so. Depending on the phase of the disease and the pattern of deformity, the more appropriate answer may be traction, a different injectable, a corrective operation once the shape has settled, or watchful waiting. The assessment exists to reach that decision, not to arrive at a predetermined one.
Confidential specialist care
Arrange a consultation to understand what is happening and to discuss the options that are actually appropriate for you — including the ones that are not treatment.